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What does MS flare up feel like? Muscle spasms. Discomfort from muscle spasms — also called spasticity — can range from mild stiffness to painful cramping. "I usually feel spasticity in my neck and shoulder areas," Sheh says. "Ice helps sometimes, but the only thing that really helps is a muscle relaxant medication."
Is there a genetic test for MS? Gene Variants May Help Diagnose MS Early. Researchers have discovered genetic variants associated with an increased risk of MS. At present, there are no laboratory tests that can detect MS, meaning that it can take years to reach a definitive diagnosis. In the meantime, damage to the central nervous system worsens.